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. 2009 Apr 7;5:260. doi: 10.1038/msb.2009.17

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Copyright © 2009, EMBO and Nature Publishing Group

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission.

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Most tissue-specific proteins interact with core cellular components, and most housekeeping proteins have tissue-specific physical interactions. (A) The proportion of the most tissue-specific proteins (proteins expressed in only 1–10/79 tissues) that interact with universally expressed housekeeping proteins. (B) The percentage of housekeeping proteins that interact with non-housekeeping proteins. These data are for the complete network. The same analysis is shown for the high-confidence multiple-support network in Supplementary Figure 2. Housekeeping proteins are defined by 10 criteria: (1) this study 79/79 tissues, (2) this study 71–79 tissues, (3) this study 79/79 tissues with reduced expression stringency, (4) this study 71–79 tissues with reduced stringency, (5) this study 79/79 tissues with increased stringency, (6) this study 71–79 tissues with increased stringency, (7) Zhu et al microarray data 18/18 tissues, (8) Zhu et al microarray data 16–18 tissues, (9) Zhu et al EST data 18/18 tissues, (10) Zhu et al EST data 16–18 tissues (Zhu et al, 2008). (C) Many proteins make interactions that can only occur in a subset of the tissues in which they are expressed. The number of tissues in which the interactions of a protein can occur is compared with the number of tissues in which a protein is expressed for proteins falling into each of the eight bins of tissue specificity. Data are shown for the complete network. Data for the filtered multiple-support network and reduced and increased stringency expression thresholds are shown in Supplementary Figure 3.