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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: J Am Coll Cardiol. 2008 Jul 1;52(1):1–12. doi: 10.1016/j.jacc.2008.03.036

Fig 6. Molecular imaging of apoptosis in atherosclerosis using radiolabeled annexin.

Fig 6

99mTc annexin A5 accumulates in an atherosclerotic lesion in the carotid artery (A, Single-photon emission computed tomography images, ->) of a patient with a recent transient ischemic attack. (B) Annexin A5 in sections of the resected plaque stains strongly in a macrophage-rich area. In contrast, minimal annexin A5 signal (C) appears in the carotid artery of a patient with a remote TI. (D) Annexin A5 immunoreactivity is at a background level in the corresponding smooth muscle cell rich lesion. Images provided courtesy of Dr. Bas Kietselaer and Dr. Leonard Hofstra, University Hospital of Maastricht, the Netherlands. Reproduced by permission from the NEJM.