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. Author manuscript; available in PMC: 2009 May 18.
Published in final edited form as: Lab Chip. 2008 Jul 23;8(9):1486–1495. doi: 10.1039/b804795b

Figure 3.

Figure 3

Dynamic adhesion of platelets to fibrinogen depends on the presence of αIIbβ3 and its cytoplasmic tail associations. A. Fluorescence micrographs showing adhesion of β3+/+ (left panel) and β3−/− platelets (right panel) to fibrinogen at 3.4 dynes/cm2, after 1 min of flow. B.C. Histograms of numbers of β3+/+ and β3Y747A platelets attached to fibrinogen within the field of view at different shear stresses in the device 1. B. Attachment to fibrinogen after 1 and 2 min of flow (average of 4 separate experiments). C. Whole blood from β3+/+ or β3Y747A mice was pre-incubated with PGE1 or ethanol vehicle control and then perfused over fibrinogen. Average values of 3 separate experiments ± SEM after 1 minute of flow are shown.