. Author manuscript; available in PMC: 2010 Mar 15.

Published in final edited form as: Arch Biochem Biophys. 2008 Sep 30;483(2):175–181. doi: 10.1016/j.abb.2008.09.012

Table 1.

A2E levels in the RPE/choroid and carotenoids in the overlying retina in 8-mm macular and peripheral punches from human eyes (mean ± SD)^*.

	Donors <50 years old (N=22)	Donors >50 years old (N=31)	Statistical significance
Age (Years)	37 ± 10	74 ± 9	P<0.0001
A2E in macula (ng)	1.3 ± 0.5	2.7 ± 1.1	P<0.001
A2E in periphery (ng)	5.1 ± 2.6	9.1 ± 4.6	P<0.0001
Iso-A2E in macula (ng)	0.1 ± 0.1	0.8 ± 0.4	P<0.01
Iso-A2E in periphery (ng)	0.5 ± 0.2	1.4 ± 0.9	P<0.0001
Total carotenoids in macula (ng)	43.6 ± 14.6	38 ± 15.1	P<0.001
Total carotenoids in periphery (ng)	2.6 ± 2.2	2.8 ± 2.8	Not significant

These data exclude outliers with unusually high levels of ocular carotenoids who had been consuming high-dose lutein supplements regularly prior to death because of potential confounding effects on data interpretation since exact dosage and duration of supplementation were unknown [16].