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. 2009 Mar 16;329(3):908–918. doi: 10.1124/jpet.109.152017

Fig. 6.

Fig. 6.

Effect of C26 treatment on cell signaling pathways. MDA-MB-435 cells were treated with 200 nM EET and/or 10 μM C26 for 24 h and then analyzed for protein expression and phosphorylation. A, decreased phosphorylation of the EGFR in MDA-MB-435 cells after C26 treatment is rescued by EETs. B, decreased PI3 kinase protein expression in MDA-MB-435 cells after C26 treatment is rescued by EETs. C, decreased phosphorylation of the Akt in MDA-MB-435 cells after C26 treatment is rescued by EETs. D, effects of EET and C26 treatments on apoptosis-related proteins in MDA-MB-435 cells. E, effects of EET and C26 treatments on metastasis-related proteins in MDA-MB-435 cells.