Fig. 4.
EtOH exposure increases BK channel activity in the nerve terminal but not in soma or dendrite. Traces of BK channel activity before and during exposure to 50 mM EtOH (Vh =-40 mV, 5 μM free Ca2+) in: A, dendrite; B, soma; or C, nerve terminal patches. C and O1, closed and open state, respectively. D, plot of the effects of various EtOH concentrations on somatic, dendritic, and terminal BK channels. The numbers within the bars represent the number of patches tested. *, statistical significance of p < 0.01. Data showing the response to 25 and 100 mM EtOH of BK channels in terminals are from a previous publication (Dopico et al., 1996).