TABLE 2.

Antepartum and postpartum pharmacokinetic parameters (arithmetic mean ± S.D.) of NFV in M. nemestrina after intra-arterial administration of the drug (NFV mesylate, 7.5 mg/kg)

Parameter Unit	AP (n = 3)	PP (n = 4)	Geometric Mean Ratio (AP/PP, 95% CI)
C0/dose (μg/ml/mg)	0.16 ± 0.05	0.70 ± 0.39	0.29 (0.10–0.82)*
AUC0-∞/dose (h · ng/ml/mg)	55.9 ± 2.71	107 ± 24.6	0.54 (0.42–0.69)*
CL (liter/h)	17.9 ± 0.87	9.82 ± 2.58	1.87 (1.46–2.40)*
CL (liter/h/kg)	2.25 ± 0.14	1.41 ± 0.38	1.63 (1.27–2.10)*
CLunbound (liter/h)	1066 ± 111	610 ± 100	1.76 (1.43–2.18)*
CLunbound (liter/h/kg)	156 ± 17.4	87.6 ± 12.0	1.79 (1.47–2.17)*
Vss (liter)	34.2 ± 2.7	13.5 ± 7.3	2.80 (1.69–4.62)*
Vss (liter/kg)	4.33 ± 0.74	1.93 ± 1.07	2.45 (1.46–4.10)*
t1/2 (h)	2.27 ± 1.01	2.12 ± 0.33	1.02 (0.62–1.67)
fu (%)	1.69 ± 0.10	1.62 ± 0.34	1.06 (0.85–1.32)

C₀/dose, dose-normalized initial plasma concentration; CL, clearance; CL_unbound, unbound clearance; V_ss, volume of distribution at steady state; t_1/2, terminal plasma half-life; f_u, unbound in plasma

^*Significantly different antepartum versus postpartum