. Author manuscript; available in PMC: 2009 Sep 1.

Published in final edited form as: Nat Genet. 2009 Feb 1;41(3):308–315. doi: 10.1038/ng.300

Table 1.

α-Syn toxicity modifiers tested in neuronal PD models

Yeast Gene	Type	Predicted function	Human orthologue	Effect in Yeast	Effect in C. elegans	Effect in rat neurons
YPK9	Suppressor	Lysosomal ATPase	ATP13A2	suppress	suppress	suppress
HRD1	Suppressor	E3 ubiquitin ligase	SYVN1	suppress	no change	suppress
UBP3	Suppressor	Ubiquitin protease	USP10	suppress	no change	suppress
PDE2	Suppressor	Phosphodiesterase	PDE9A	suppress	suppress	suppress
CDC5	Suppressor	Polo-like kinase	PLK2	suppress	suppress	suppress
YCK3	Suppressor	Casein kinase	CSNK1G3	suppress	no change	no change