Table 2.
Correlation analysis of variables and clopidogrel low response.
| Variables |
Low Responder patients* N = 6 |
Intermediate plus High Responder patients* N = 46 |
P value |
| Age | 62 ± 13.2 | 64 ± 10.7 | 0.671 |
| Male | 4 (66) | 35 (76) | 0.472 |
| Body mass index, kg/m2 | 26 ± 3.3 | 26 ± 4.3 | 0.956 |
| Ejection fraction % | 54 ± 3.7 | 52 ± 9.6 | 0.652 |
| Hematocrit % | 36.2 ± 7.8 | 37 ± 8 | 0.774 |
| Platelet count (× 103/μL) | 268 ± 124 | 235 ± 130 | 0.439 |
| Current smoking | 1 (17) | 4 (87) | 0.487 |
| Diabetes | 1 (17) | 13 (29.5) | 0.663 |
| -Insulin dependent Diabetes | 0 | 6 (15) | 0.444 |
| Chronic renal failure | 0 | 2 (43) | 0.772 |
| Hypertension | 3 (50) | 29 (63) | 0.369 |
| Hypercholesterolemia | 3 (50) | 28 (61) | 0.412 |
| Statins | 6 (100) | 32 (70) | 0.136 |
| CYP3A4-metabolizing statins | 5 (83) | 23 (50) | 0.134 |
Values are expressed as means ± SDs or number (percentages) of patients.
*Defined by flow cytometric evaluation of platelet activation parameters.