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. Author manuscript; available in PMC: 2010 Jun 5.
Published in final edited form as: J Control Release. 2009 Feb 3;136(2):99–109. doi: 10.1016/j.jconrel.2009.01.016

Fig. 3.

Fig. 3

Impact of cyclic strain on drug penetration. (A) Cyclic loading significantly increased penetration linearly proportionally to loading frequency (T-test, p<0.05 except groups with * in between). 0 Hz groups are static cases in Fig. 2 A. (B) Slopes of the linear relationship between penetration and loading frequency at each mean strain were statistically the same (Single-Factor ANOVA, p>0.05). (C) Penetration profiles at each loading frequency. (D) Penetration at each strain was directly dependent on the number of loading cycles (Two-Factor ANOVA, p<0.05 between 0% and 5%, p>0.05 among loading groups). 1 Hz-60 min groups are those in Fig. 3A.