Table 6. Prioritizer analysis of literature-derived autism susceptibility loci.
| Locus | Top ten ranked genes from topology-corrected Prioritizer analysis. |
| 1q42.2 (D1S1656) | TRIM11 (0.002), NP_115811.1 (0.007), EXOC8 (0.015), ERO1LB (0.015), FMN2 (0.036), HIST3H3 (0.046), DEGS1 (0.047), B3GALNT2 (0.061), TRIM17 (0.066), SIPA1L2 (0.077) |
| 2q31.1 (D2S2188) | LRP2 (0.007), SCN1A (0.012), CYBRD1 (0.015), GAD1 (0.018), MTX2 (0.026), DHRS9 (0.033), NOSTRIN (0.050), ENH1_HUMAN (0.063), SCN2A2 (0.082), B3GALT1 (0.095) |
| 2q37 | SEPT2_HUMAN (0.003), NP_612209.1 (0.053), GAL3ST2 (0.060), GPR35 (0.072), SH3BP4 (0.076), RAMP1 (0.121), GBX2 (0.174), MLPH (0.185), AGXT (0.222), BOK (0.268) |
| 3q26.32 (D3S3037) | GAW2_HUMAN (0.008), NP_872343.2 (0.021), NLGN1 (0.042), SIAT1_HUMAN (0.048), B3GNT5 (0.064), NM_003002.1 (0.069), DNAJB11 (0.100), TBL1XR1 (0.136), MYNN (0.142), PSMD2 (0.148) |
| 5p15 | SEC6L1 (0.007), NP_954584.1 (0.032), XP_059689.3 (0.046), DAP (0.143), SLC9A3 (0.165), SRD5A1 (0.187), MTRR (0.219), IRX1 (0.281), SLC12A7 (0.284), SLC6A3 (0.292) |
| 7q22.1 (D7S477) | CYP3A5 (0.003), CYP3A7 (0.003), CYP3A43 (0.003), CYP3A4 (0.007), GJE1 (0.008), FZD1 (0.019), MCM7 (0.035), BCAP29 (0.056), KRIT1 (0.058), MLL5 (0.059) |
| 7q36.2 (D7S2462) | EFC2_HUMAN (0.007), PDIA4 (0.016), NP_065178.1 (0.030), ABCB8 (0.046), SHH (0.059), RNF32 (0.065), DPP6 (0.092), GIMAP6 (0.096), GALNTL5 (0.102), NOS3 (0.103) |
| 15q11–14 | MKRN3 (0.009), TUBGCP5 (0.011), O60374_HUMAN (0.031), UBE3A (0.051), NIPA2 (0.078), NP_001019852.1 (0.128), KLF13 (0.144), NP_061831.1 (0.161), NP_055782.2 (0.260), GREM1 (0.370) |
| 17q11.2 (D17S1294) | ALDH3A1 (0.011), PRR6 (0.015), ALDH3A2 (0.020), Q6NXQ4_HUMAN (0.026), PIGW (0.030), ACCN1 (0.039), ZPBP2_HUMAN (0.040), PIGS (0.049), DUSP14 (0.050), PM1_HUMAN (0.057) |
| 18q21–23 | FECH (0.013), RAB27B (0.023), POLI (0.030), PIGN (0.039), KIAA0427 (0.044), MBP (0.106), ST8SIA5 (0.120), ZNF236 (0.123), CNDP1 (0.140), PHLPP_HUMAN (0.157) |
| 22q11.2 | SLC25A1 (0.004), SDF2L1 (0.019), ENK11_HUMAN (0.034), DGCR2 (0.073), GSCL (0.075), RTN4R (0.092), COMT (0.108), PPM1F (0.152), CLDN5 (0.177), SEPT5 (0.233) |
| 22q13.3 | TUBGCP6 (0.006), MLC1 (0.046), ALG12 (0.070), MAPK11 (0.113), ADM2 (0.125), CERK (0.128), MAPK8IP2 (0.213), ARSA (0.260), PLXNB2 (0.286), TBC1D22A (0.301) |
| Xp22 | MID1 (0.005), PCYT1B (0.015), NLGN4X (0.015), HCCS (0.020), ASMT (0.034), Q7Z4W4_HUMAN (0.040), CNKSR2 (0.040), GLRA2 (0.068), PLCXD1 (0.095), PTCHD1 (0.120) |
The ten most significant genes identified from topology-corrected Prioritizer analysis of the 13 non-overlapping literature-derived autism susceptibility loci are given per locus (sorted on P-Value). Genes related to glycobiology are in bold. P-values for individual genes are given between brackets.