Figure 6. Modulation of the ASIC-like current by lactate (A), low Ca²⁺ (B), and Zn²⁺ (C).

A, 30 mm lactate potentiated the current response to pH 6.4 in a representative cell (left panel). Right panel: summary of experiments showing the potentiation by 30 mm lactate of the current response to pH 6.4 (n= 6). B, 0.5 mm Ca²⁺ potentiated the current response to pH 6.4 in a representative cell (left panel). Right panel: summary of experiments showing the potentiation by 0.5 mm Ca²⁺ of the current response to pH 6.4 (n= 6). C, 300 μm Zn²⁺ inhibited the current response to pH 5.4 in a representative cell (left panel). Right panel: summary of experiments showing the inhibition by 300 μm Zn²⁺ of current responses to pH 6.4 (n= 5), 5.4 (n= 14), and 4.4 (n= 2).