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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Mol Pharm. 2009;6(2):396–406. doi: 10.1021/mp800120t

Figure 3.

Figure 3

DOX-cIBR7 conjugate entry into the HL-60 cells was not affected by change in temperature as evaluated by an epifluorescence microscope. Panel a) illustrates that DOX-cIBR7 showed diffuse fluorescence distribution in the cell cytoplasm after incubation at 37 °C. It did not show the punctate intracellular stain indicative of endocytosis. Panel b) demonstrates that incubation at 4 °C did not inhibit the conjugate entry or change the distribution pattern. For comparison, profiles of the cells incubated with DOX at 37 °C and 4 °C are shown in panels c) and d), respectively.