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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Mol Pharm. 2009;6(2):396–406. doi: 10.1021/mp800120t

Figure 4.

Figure 4

An increase in hydrophilicity of the DOX-PEGcIBR7 conjugate did not change the cellular entry mechanism or the distribution pattern compared to DOX-cIBR7 in HL-60 cells evaluated by epifluorescence microscope. Panel a) shows cells incubated with DOX-PEGcIBR7 at 37 °C. Panel b) shows cells incubated with DOX-PEGcIBR7 at 4 °C. Under both conditions, the conjugate showed diffuse cytoplasmic fluorescence distribution patterns. Profiles of the cells incubated with DOX at 37 °C and 4 °C are shown in panels c) and d), respectively.