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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Mol Pharm. 2009;6(2):396–406. doi: 10.1021/mp800120t

Figure 5.

Figure 5

FITC-cIBR7 showed temperature-dependent internalization in HL-60 cells evaluated using a confocal microscope. Panel a) shows cells incubated with FITC-cIBR7 at 37 °C. Distinct localization of FITC-cIBR7 is indicative of an endocytic uptake pathway. b) Incubation of the cells at 4 °C prevented the endocytic uptake of FITC-cIBR7, suggesting that the entry was energy-dependent. As a control, FITC-dextran internalization profiles at 37 °C and 4 °C are shown in panels c) and d), respectively.