Figure 8.

(A) Peak inspiratory pressure changes during high-stretch mechanical ventilation of either untreated animals or animals pretreated with clodronate liposomes for 24 hours before ventilation. Pressure changes over time during ventilation were different between the treatment groups as indicated by a significant interaction P value by two-way analysis of variance (P < 0.05). (B) Change in respiratory system compliance and (C) resistance, during high-stretch ventilation of either untreated animals or animals pretreated with clodronate liposomes for 24 hours before ventilation. Mechanics changes are expressed as percentage of increase in respiratory system compliance (Crs) or respiratory system resistance (Rrs) between 30 minutes after start of protocol and the end of protocol. n = 5. *P < 0.05, by unpaired t tests. clod = clodronate liposomes; VILI = ventilator-induced lung injury.