TABLE 2.
BASELINE PHYSIOLOGICAL VARIABLES OF HIGH-STRETCH VENTILATED ANIMALS WITH/WITHOUT TREATMENTS
| No Pretreatment | LPS | LPS + clod 24 h | LPS + clod 48 h | |
|---|---|---|---|---|
| BP, mm Hg | 83 ± 14 | 80 ± 10 | 85 ± 14 | 91 ± 21 |
| Crs, ml/kg/cm H2O | 1.66 ± 0.09 | 1.57 ± 0.15 | 1.56 ± 0.11 | 1.62 ± 0.19 |
| Rrs, cm H2O/ml/s | 1.62 ± 0.10 | 1.62 ± 0.16 | 1.74 ± 0.31 | 1.70 ± 0.20 |
| Po2, mm Hg | 125 ± 10 | 128 ± 8.5 | 125 ± 11 | 119 ± 11 |
| Pco2, mm Hg | 36.3 ± 2.2 | 34.3 ± 2.5 | 33.0 ± 4.0 | 33.6 ± 2.9 |
| pH | 7.372 ± 0.04 | 7.377 ± 0.04 | 7.437 ± 0.02* | 7.385 ± 0.04 |
Definition of abbreviations: BP = mean arterial blood pressure; clod = clodronate liposomes; Crs = respiratory system compliance; LPS = lipopolysaccharide; Rrs = respiratory system resistance.
Baseline physiological variables (i.e., before change to high-stretch protocol) of either untreated animals, LPS-challenged animals, or animals treated with clodronate liposomes for 24 or 48 hours and then challenged with LPS.
* P < 0.05 versus LPS challenged mice by analysis of variance with Bonferroni tests.