Skip to main content
. 2009 Feb 20;179(10):955–961. doi: 10.1164/rccm.200811-1728OC

Figure 5.

Figure 5.

Recombinant human IL-1 receptor antagonist (rhIL-1ra) decreases intraamniotic LPS-induced lung maturation. Quantification of surfactant protein mRNA by S1 nuclease protection assay, 2 days after exposure. (A) SP-A, (B) SP-B, and (C) SP-C mRNAs from fetal lung normalized to L32 (ribosomal protein mRNA), 2 days after exposure. The mean mRNA signal in control animals was given the value of 1 and levels at each time point were expressed relative to controls. (D) Bronchoalveolar lavage fluid (BALF) surfactant saturated phosphatidylcholine (Sat PC) and (E) deflating limb pressure–volume curve, 7 days after exposure. rhIL-1ra inhibited intraamniotic LPS-induced lung maturation (†P < 0.05 vs. control, *P < 0.05 vs. intraamniotic LPS, exposure).