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. 2009 Feb;21(1):30–37. doi: 10.1016/j.coi.2009.01.003

Figure 2.

Figure 2

Dectin-1 expressing cells are positioned at portals of pathogen entry and sites of T cell development. Dectin-1 is expressed in the dermal layers of skin and palate (arrowheads) but not on the Langerhans cells. Dectin-1 is also expressed on lung APCs and in the gut, Dectin-1+ cells are located in the villi and Peyer's patches (arrowhead). In lymphoid tissues, Dectin-1+ cells are found in all areas including the germinal centres (small arrowhead in lymph node) and T cell regions around the central arteriole (small arrowhead) in the splenic white pulp. The organised nasal associated lymphoid tissues (O-NALT) demonstrate regional similarities to the lymph node. In the thymus, Dectin-1+ cells appear concentrated at the corticomedullary junctional regions. E: epidermis; D: dermis; PP: Peyers’ patch; B: B cell area; T: T cell area; GC: germinal centre; C: cortex; M: medulla.