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. 2009 May 7;7:21. doi: 10.1186/1741-7007-7-21

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Copyright © 2009 Higuchi et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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PsGEF functions as a GEF for Rac in cultured cells. HeLa cells transiently transfected with DmPsGEF RhoGEF domain expression constructs were stained with fluorescein isothiocyanate-phalloidin to detect F-actin (A and D), and anti-myc antibodies were used to detect the RhoGEF domain of DmPsGEF (B and E). The images A and B are merged to form image (C), and the images D and E are merged to form image (F). Actin polymerization in membranes, which results in membrane ruffling, is specifically observed in cells that express the RhoGEF domain of DmPsGEF (arrowheads in C and F).