Table 2.
Classification of human ABC subfamily B transporters, including alias, transporter architecture and substrate specificities.
| Gene | Alias | Architecture | Substrate |
|---|---|---|---|
| ABCB1 | PGY1, MDR | F | Drug |
| ABCB2 | TAP1 | H | Peptide (ER) |
| ABCB3 | TAP2 | H | Peptide (ER) |
| ABCB4 | PGY3 | F | PC |
| ABCB5 | H | Drug | |
| ABCB6 | MTABC3 | H | Fe (OM) |
| ABCB7 | ABC7 | H | Fe/S cluster (IM) |
| ABCB8 | M-ABC1 | H | Peptide (IM) |
| ABCB9 | TAPL | H | Peptide (LY) |
| ABCB10 | M-ABC2 | H | Peptide (IM) |
| ABCB11 | SPGP | F | Bile salt |
Abbreviations: F: Full transporter; H: Half transporter; OM: outer mitochondrial membrane; IM: inner mitochondrial membrane; LY: lysosome.