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. 2007 Aug 8;3:121–158.

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Copyright © 2007 The authors.

This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0.

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Figure 7. — The HIPPO (hpo)-Large tumor suppressor (Lats) pathway validated in Drosophila melanogaster and its similar pathway recently postulated in mammals. The network involves Hippo (Hpo), Salvador (Sav), Lats1/Warts (dNDRs), Mats (Mob as tumor suppressor, dMob1) and Yorkie (Yki) factors, and participates to the control of tissue growth by regulating cell cycle arrest and cell death. In Drosophila Hpo interacts with Sav, which acts as a scaffold protein, and phosphorilates Warts-Mats. Activated Warts can negatively regulate the transcription of cell cycle and cell death regulators such as cyclin E and the apoptosis inhibitor DIAP1, through the phosphorilation of the non-DNA binding transcriptional co-activator Yorkie. All components of the HIPPO pathway are well conserved in mammals and they have a similar function in humans since Lats1 (Warts), Mob1A (Mats), MST2 (Hippo) and Yap (Yorkie) genes can all functionally rescue their correspondent Drosophila mutants.