Table 1.

Summary of available data on Mob-domain containing proteins and its interacting NDR-type kinases (see footnotes for main References).

Organism	Protein name	Accession	Description/Function	Group	Subcellular localization	Interacting kinases
Saccharomyces cerevisiae1	Mob1p	NP_012160	Component of the MEN: regulates mitotic exit and cytokinesis	-	Spindle pole body and bud neck	Dbf2p-Dbf20p
	Mob2p	NP_116618	Component of the RAM signaling network: links cell morphology changes with cell cycle progression	-	Nucleus, cytoplasm and cortex	Cbk1p
Schizosaccharomyces pombe2	Mob1p	NP_595191	Component of the SIN: controls septum initiation and cytokinesis	-	Spindle pole body and mitotic septum	Sid2p
	Mob2p	NP_587851	Required for maintenance of cell polarity: coordinates cell morphogenesis with cell cycle progression	-	Mitotic septum	Orb6p
Caenorhabditis elegans3	-	NP_510184	F09A5.4c	-
	-	NP_502248	F38H4.10	-
	-	NP_498798	C30A5.3	3
	-	NP_501179	T12B3.4	4
Drosophila melanogaster4	dMob1	NP_729716	CG11711-PB. Mob1, isoform B	2		Trc (dNDR)/Warts (Lats)
	Mats	NP_651041	CG13852-PA. Mob as tumor suppressor	1		Trc (dNDR)/Warts (Lats)
	dMob3	NP_609364	CG4946-PA	4		-
	dMob4	NP_610229	CG3403-PA	3		-
Homo sapiens5	hMOB1	NP_775739	MOB-KL1A, MOB kinase activator-like 1A (MOB1A)	1	Nucleus, cytoplasm and membrane	LATS1/2 (low affinity for NDR1/2)
	MATS1	NP_060691	MOB-KL1B, MOB kinase activator-like 1B (MOB1B)	1	Centrosome, poles of mitotic spindle and midbody	LATS1
	hMOB2	NP_443731	HCCA2 protein	2	Nucleus, perinuclear region and cytoplasm	NDR1/2
	hMOB3A	NP_955776	PREI3, preimplantation protein (Phocein)	3	Perinuclear region, membrane	PP2A
	hMOB3B	NP_079037	MOB-KL2B, MOB kinase activator-like 2B	4b
	hMOB3C	NP_958805	MOB-KL2C, MOB kinase activator-like 2C	4a
	MOB-LAK	NP_570719	MOB-LAK, metal ion binding	4b	Intracellular
Arabidopsis thaliana6	Mob1A	NP_199368	Similar to yeast Mob1p	p	Nucleus
	Mob1B	NP_193640	Mob1-like domain containing protein	p
	Mob2A	NP_197544	Similar to yeast Mob2p	p	Nucleus
	Mob2B	NP_197543	Similar to yeast Mob2p	p	Fragmoplast
Medicago sativa7	Mob1A	CAC41010	Similar to yeast Mob1p	p	Cytoplasm and cell plate
	Mob1B	CAG25780	Similar to yeast Mob1p	p
Trypanosoma brucei8	Mob1A	AAL10512	Mob1-1 essential for cytokinesis but not for mitotic exit	-	Cytoplasm	tbPK50 (functional homolog of Orb6)
	Mob1B	AAL10513	Cell cycle associated protein Mob1-2	-

¹Luca et al. (1998); Luca et al. (2001); Komarnitsky et al. (1998); Mah et al. (2001); Stegmeier et al. (2002); Weiss et al. (2002); Mah et al. (2005); Stoepel et al. (2005).

²Verde et al. (1998); Salimova et al. (2000); Hou et al. (2003; 2004).

³No references.

⁴Geng et al. (2000); He et al. (2005); Lai et al. (2005).

⁵Moreno et al. (2001); Bichsel et al. (2004); Devroe et al. (2004); Hergovich et al. (2005); Lai et al. (2005); Bothos et al. (2005); Hergovich et al. (2006).

⁶VanDamme et al. (2004); Barcaccia et al. (unpublished).

⁷Citterio et al. (2005); Citterio et al. (2006).

⁸Hammarton et al. (2005).