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. 2007 Sep 26;3:357–370.

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Copyright © 2007 The authors.

This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0.

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Figure 2. — Phylogeny of rhodopsin GPCR groups. GPCR phylogeny based on reconstructed ancestors. Six principal clades are resolved within which genetic distances between reconstructed ancestors and extant sequences do not exceed κ. The principal clades are labeled A–F as follows. A. Nucleotide receptor group: includes peptide, nucleotides and lipid receptors. B. The endocrine hormone receptor group: includes peptide receptors involved with endocrine hormones. C. The opioid receptor group: includes opioid, somatostatin and galanin related peptide receptors. D. The neuropeptide receptor group: includes peptide receptors involved with endocrine hormones and neuropeptides. E. The mas receptor group: includes nociceptive mas and mas related receptors. F. The amine receptor group: includes biogenic amine, rhodopsin, arachodonic and peptide and lipid receptors. The remaining ancestors to groups are not included in major families because the genetic distance between them and all other taxa is aberrantly high.