Figure 5.

Amino acid alignment of phylogenetic mosaicism between orexin and adrenergic receptors in the first cytoplasmic domain. Alignment of the first cytoplasmic domain in the gastrin and the adrenergic receptor groups. Adrenergic group receptors are shown in black, gastrin group receptors in grey. The nearest neighbors identified by the HTP analysis, orexin and alpha-1B adrenergic receptor, have matching residues highlighted in purple bold. The reconstructed ancestral sequence for the adrenergic (ancestor 17) and gastrin (ancestor 6a) receptors are shown at the bottom of the alignment.