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Study timeline. Treatment was initiated 6 wk after OVX surgery in female Sprague-Dawley rats. Animals were treated 3 times/wk for 8 wk with either 0.3 ml saline (CON), ALN (2.4 μg/kg), RIS low (1.2 μg/kg), or RIS high (2.4 μg/kg). Ten animals per treatment group were killed at 0, 4, 8, 12, and 16 wk after treatment was withdrawn. OVX, ovariectomized; L, bone label calcein administered 10 and 4 days before death; S, 10 rats per treatment group were killed.
