Table 4.

Tumor Onset, Growth, and Incidence of Lung Metastases in MMTV-neu Mice by Caveolin-1 Genotype

Genotype	Cav-1+/+	Cav-1+/−	Cav-1−/−
Number of mice	25	43	9*
Age at tumor onset (days ± SEM)	404 ± 24	343 ± 15	303 ± 15
Age at harvest (days ± SEM)	469 ± 26	407 ± 16	354 ± 17
Tumor growth (days ± SEM)	65 ± 5	64 ± 4	51 ± 6
Median survival (days)	454	384	361
Incidence of visible lung mets (%)	28	23	20

Significance differences in tumor onset time were assessed by the Gehan-Breslow-Wilcoxon test. P = 0.002 for the difference between Cav^+/+ and Cav^−/− mice and P = 0.026 for the difference between Cav^+/+ and Cav^+/− mice. 

^*Only 9 of the original 15 mice were available for final analysis due to losses from non-tumor related causes during the experiment.