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. 2009 Jun;174(6):2182–2189. doi: 10.2353/ajpath.2009.080914

Figure 5.

Figure 5

Lungs of uPAR−/− mice show less injury. Representative H&E stainings of lung tissue of wild-type (Wt) mice exposed to room air (control, A and E) and of wild-type (B and F) and uPAR−/− mice (C and G) exposed to 80% oxygen for 4 days. Original microscopic magnification A–C: ×20. Graphical representation of the mean histology score of lung inflammation (D) determined according to the scoring system described in the Materials and Methods section. Less profound necrosis of the bronchial epithelium was observed in the uPAR−/− mice (G, arrow) compared with wild-type mice (F, arrow). Original microscopic magnification E–G: ×10. Graphical representation of the degree of necrosis of bronchial epithelium (H) determined according to the scoring system described in the Materials and Methods section. Arrow in E indicates bronchial epithelium of a healthy lung from wild-type mouse exposed to room air. Representative PAS-D stainings of lung tissue of wild-type mice exposed to room air (control, I) and of hyperoxia exposed wild-type (J, arrows indicate enhanced PAS-D staining, indicative for hyaline membranes) and uPAR−/− mice (K). Original microscopic magnification I–K: ×20. *P < 0.05 versus wild-type mice.