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. 2009 Jun;174(6):2182–2189. doi: 10.2353/ajpath.2009.080914

Figure 6.

Figure 6

Lower total protein and alkaline phosphatase levels in uPAR−/− mice. Wild-type (Wt) (open bars) and uPAR−/− mice (closed bars) were exposed to either 80% oxygen (A–D) or room air (control mice, C) and sacrificed after 4 days. Total protein (A) and AF (B) were measured in BALF. Levels of healthy wild-type and uPAR−/− mice were 23.4 ± 1.9 and 7.6 ± 3.8, respectively, for total protein and below detection limit for alkaline phosphatase (data not shown). Western blot was performed for soluble receptor for advanced glycation end products (sRAGE) in BALF of healthy control mice (C) and of mice exposed to hyperoxia (C and D). Semiquantitative data were generated by densitometric evaluation of wild-type versus uPAR−/− mice 4 days after oxygen exposure (D). AU = arbitrary units. Data are mean ± SE of 6 to 10 mice per genotype. *P < 0.05 versus wild-type mice; **P < 0.01 versus wild-type mice; ***P < 0.001 versus wild-type mice.