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. 2009 Jun;174(6):2202–2210. doi: 10.2353/ajpath.2009.081041

Figure 2.

Figure 2

Effect of nasal administration of pCol (24-38) in groups of WKY rats (n = 5 to 6) after the onset of disease on albuminuria at different time points after immunization: positive control (POS) (filled circles), negative control (NEG) (open circles), pCol (24-38) 300 μg nasally (filled squares), pCol (24-38) 1000 μg nasally (open squares), and pCol (24-38) 3000 μg nasally (filled triangles) (A) and glomerular abnormalities at day 28 after immunization: severe (extensive segmental necrosis/crescent formation), abnormal (segmental necrosis and/or extracapillary proliferation), or normal (B). Results shown represent the mean ± SD of each group. *P < 0.01, positive control (POS) versus pCol (24-38) 1000 μg nasally; **P < 0.001, positive control (POS) versus pCol (24-38) 3000 μg nasally.