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. 2009 Jun;174(6):2300–2309. doi: 10.2353/ajpath.2009.081153

Figure 6.

Figure 6

Data are medium concentrations of secreted IL-6 (A) or MCP-1 (B) by primary wild-type (wt) or EP1−/− microglia determined 8 and 24 hours of incubation with LPS or PBS. LPS-stimulated secretion of both cytokines was suppressed by ablation of EP1. A: Two-way analysis of variance for medium IL-6 at 8 hours had P < 0.0001 for exposure, P < 0.0001 for genotype, and P < 0.0001 for interaction; similar results were obtained at 24 hours (not shown). Bonferroni-corrected post-tests had *P < 0.001 for LPS exposed wild type versus EP1−/−. B: Two-way analysis of variance for medium MCP-1 at 24 hours had P < 0.0001 for exposure, P < 0.001 for genotype, and P < 0.01 for interaction; MCP-1 was undetectable at 8 hours (not shown). Bonferroni-corrected post-tests had *P < 0.001 for LPS exposed wild type versus EP1−/−.