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. 2009 Jun;174(6):2337–2346. doi: 10.2353/ajpath.2009.080848

Figure 2.

Figure 2

Relation of Xbp-1 with other transcription B cell transcription factors. Human tonsil. A: Pax-5 is expressed in virtually all B cells, only in the light zone of the germinal centers a small fraction of cells lack Pax-5 and express nuclear Xbp-1, in a mutually exclusive pattern (×20). B: Bcl-6 expression is restricted to germinal centers and only Bcl-6 negative centrocytes expressed nuclear Xbp-1 (×20). C: The plasma cell associated transcription factor Irf-4 is coexpressed in all nuclear Xbp-1 positive cells (×20).