Table 2.

Xbp-1 Activation in B-Cell and Plasma Cell Tumors

Diagnosis	Nuclear Xbp-1 IHQ	XBP1s/XBP1u mRNA
Chronic lymphocytic leukemia	0/17*	.011
Follicular lymphoma	0/12	.012
Mantle cell lymphoma	4/25 (16%)	.040
Splenic marginal zone lymphoma	0/4
Marginal zone lymphoma	0/5†	.036
Burkitt lymphoma	3/15 (20%)	.092
DLBCL	37/126 (29%)
GCB	15/53 (28%)	.105
Non-GCB	22/73 (30%)	.143
Plasmablastic lymphoma	25/54 (46%)	.122
PEL	4/6 (67%)
Plasmacytoma	27/39 (69%)	.301
Classical Hodgkin lymphoma	0/40
Peripheral T-cell lymphoma	0/11

ND: Not done; DLBCL: Diffuse large B-cell lymphoma; GCB: Germinal center type DLBCL; PEL: Primary effusion lymphoma. 

^*Scattered cells positive in the proliferative growth centers. 

^†Scattered plasma cells positive.