Figure 1.
Inhibition of Erbb2 suppresses UV-induced skin tumorigenesis. A: Experimental design showing treatment of mice in the tumor experiment. Groups of 10 mice were pretreated with AG825 or the vehicle DMSO alone 2 hours before 10 kJ/m2 UV or sham irradiation. This treatment was repeated one week later. At 12 weeks after the initial UV exposure, mice were euthanized and skin or tumors was removed for analysis. Hash marks on the timeline indicate the spacing is not correct to scale. B: Mean tumor number per mouse ± SEM (left axis) and tumor volume ± SEM (right axis) are shown. *Significantly different when compared with the vehicle-treated and UV-exposed group using a two-way ANOVA, where P ≤ 0.05.