Table 2.
Diagnostic accuracy of different non-invasive assays
| Number of cases | Type of assay | Sensitivity (%) | Specificity (%) | |
|---|---|---|---|---|
| Case-control studies | ||||
| Halling et al.[12] | 265 | FISH | 81 | 96 |
| Skacel et al.[16] | 120 | FISH | 85 | 97 |
| Placer et al.[13] | 86 | FISH | 80 | 85 |
| Riesz et al.[17] | 55 | FISH | 87 | 100 |
| Varella-Garcia et al.[14] | 19 | FISH | 87 | 100 |
| Halling et al.[18] | 265 | FISH | 81 | 100 |
| BTA stat | 78 | 74 | ||
| Sarosdy et al.[11] | 176 | FISH | 71 | 100 |
| BTA stat | 50 | - | ||
| Saad et al.[23] | 120 | NMP22 | 81 | 87 |
| BTA stat | 63 | 82 | ||
| Babjuk et al.[22] | 218 | BTA stat | 74 | 87 |
| BTA TRAK | 76 | 73 | ||
| UBC rapid | 49 | 79 | ||
| UBC IRMA | 70 | 64 | ||
| May et al.[15] | 166 | FISH | 53 | 74 |
| UBC | 40 | 75 | ||
| Eissa et al.[26] | 168 | NMP22 | 85 | 91 |
| UBC | 67 | 81 | ||
| Adb El Gawad et al.[21] | 86 | NMP22 | 91 | 87 |
| BTA | 100 | 92 | ||
| Symptomatic patients | ||||
| Sarosdy et al.[20] | 497 | FISH | 69 | 78 |
| Laudadio et al.[19] | 300 | FISH | 73 | 65 |
| Grossman et al.[27] | 1331 | NMP22 | 56 | 86 |
| Sharma et al.[24] | 278 | NMP22 | 82 | 82 |
| BTA stat | 68 | 82 | ||
| Atsü et al.[28] | 82 | NMP22 | 78 | 66 |
| Landman et al.[25] | 77 | BTA | 40 | 73 |
| NMP22 | 81 | 77 |
FISH = fluorescence in situ hybridization, BTA = bladder tumor antigen, NMP22 = nuclear matrix protein, UBC = urinary bladder cancer Tabulated according to size of case-series within each marker