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. Author manuscript; available in PMC: 2009 May 19.
Published in final edited form as: Neurobiol Aging. 2006 Dec 14;29(4):524–541. doi: 10.1016/j.neurobiolaging.2006.11.008

Table 3.

Differentially expressed transcripts located in genomic regions linked to Alzheimer’s diseasea

# of transcripts
Linkage Regions # DEb # on chipc p-valued
1p36 106 808 0.99
1q23-31 78 511 0.70
2p23-24 49 285 0.43
4q35 15 84 0.44
5p13-15 64 325 0.12
6p21 92 750 0.99
6q15-16 27 112 0.05
6q25-27 46 280 0.55
9p21 11 67 0.56
9q22 26 219 0.96
10q21-22 55 319 0.42
10q25 22 120 0.37
12p11-12 30 219 0.86
19q13 144 1256 1.00
21q21-22 66 499 0.96
Xp11-21 42 321 0.94
a

Linkage regions are reproduced from Bertram and Tanzi [6]. Transcripts differentially expressed (DE) between non-demented and AD subjects (hypothesis I) were compared for overrepresentation in linkage regions.

b

DE, number of transcripts differentially expressed at q < 0.1 by ANOVA that are located in the linkage region

c

Number of transcripts on the chip that are located in the linkage region

d

p-values are from Fisher’s Exact test comparing transcripts DE at q < 0.1 to all transcripts on the Affymetrix HGU133Plus2 GeneChip in each linkage region.