Table 5.

Canonical Pathways involved in healthy aging

Pathway	# genesa	# genes in pathwayb	p-valuec	% Ad
Oxidative phosphorylation	66	130	0.000	50.769
Proteasome	20	31	0.000	64.516
ATP synthesis	22	40	0.000	55.000
Infection	18	41	0.009	43.902
Citrate cycle (TCA cycle)	12	25	0.014	48.000
Synthesis and degradation of ketone bodies	5	7	0.015	71.429
RNA polymerase	11	23	0.019	47.826
Carbon fixation	10	22	0.037	45.455
Phenylalanine	6	11	0.041	54.545
Butanoate metabolism	17	44	0.044	38.636
Amyotrophic lateral sclerosis (ALS)	8	17	0.049	47.059
Reductive carboxylate cycle (CO2 fixation)	5	9	0.056	55.556
Valine	16	43	0.068	37.209
Aminoacyl-tRNA biosynthesis	10	25	0.088	40.000

^athe number of differentially expressed genes (q < 0.1 by ANOVA) that are members of the pathway

^bthe total number of genes in the pathway

^cp-values are from a one-tailed Fisher’s Exact Test (see methods)

^d% abundance of differentially expressed genes in that pathway