Table 3.

Effect of Placebo and Allopurinol on Non–Blood Pressure End Points

	Mean (95% Confidence Interval)
Parameter	Pretreatmenta	Placebo	Allopurinol	P Value
Heart rate, beats/min	72 (67–78)	74 (69–80)	75 (69–80)	.87
Cardiac output, L/min	6.4 (5.6–7.1)	6.2 (5.4–7.0)	6.6 (5.9–7.2)	.56
Systemic vascular resistance index, (dyne s/cm5)/m2	2478 (2223–2731)	2473 (2232–2615)	2136 (2056–2228)	.03b
Total body water, L	27.8 (26.0–29.7)	28.0 (26.1–30.1)	28.1 (26.0–29.9)	.86
Plasma renin activity, ng/mL/h	1.9 (1.7–2.2)	2.1 (1.8–2.4)	1.4 (0.8–2.1)	.02b

^aPretreatment values were measured prior to first treatment phase.

^bExploratory end points.