Table 1.
Summary of the main modules and submodules identified using Polar Mapper as being more strongly upregulated or downregulated under the hydrogen peroxide or heat shock stimulus in yeast. (See the main text for analysis.)
| hydrogen peroxide | heat shock | |
|---|---|---|
| stronger downregulation | chromosome condensation/segregation | large 60S ribosomal subunit |
| cytokinesis/chromosome segregation | small 40S ribosomal subunit | |
| anaphase-promoting complex (submod. 55)a | translation initiation complex | |
| exosome complex | ||
| nucleoplasmic RNA/protein transport | ||
| core RNA polymerase | ||
| stronger upregulation | DNA repair submodule (submod. 57)b | protein folding submodule (submod. 100) |
| G1/S submodule (submod. 98) | proteasomal catalytic complex |
a
The APC submodule does not show a clear trend towards downregulation during heat shock.
b
The DNA repair submodule, in fact, shows a downregulation trend during heat shock.