Table 2.

Study scheme

Study assessment	d 1		d 2
	1800 h	2200 h	0600 h	1200 h	1800 h	2200 h
ACTH measurement		Ö	Ö
Dexamethasone 1 mg orally	Ö	Ö	Ö	Ö	Ö
20a Subjects dosed with MR-HC 5, 15, or 30 mg, or IR-HC 10 mg
12 Subjects dosed with MR-HC 10 mg or IR-HC 10 mg		Ö

Subjects were admitted to the Clinical Research Facility on d 1, and were tested on up to three occasions with a 1-wk washout between treatments. Cortisol measurement, pre-dose at 2200 h and post-dose sampling every 30 minutes for the first 4 h, then at 5, 6, 7, 8, 10, 12, 15, 18, and 24 h after dose. 

^aFour subjects withdrawn.