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Effect of progestin on AKT pathway. A, Leiomyoma cells were treated with 100 nm R5020 for 1 h. Levels of phospho(Ser473)-AKT, total AKT, phospho-GSKβ, GSKβ, phospho(Ser256)-FOXO1, and FOXO1 proteins were detected by Western blot. B, Leiomyoma cells were treated with 100 nm R5020 for 1 h. Nuclear and cytoplasmic fractions were isolated and levels of total FOXO1 were detected in each fraction by Western blot. C, Control; R, R5020.
