Figure 1.

Severe burn injury leads to significant alterations of the metabolic response. A and B, Urinary epinephrine and norepinephrine increase initially after burn injury and then decrease to normal levels at around 2 months after injury. C, Twenty-four-hour total urine cortisol levels increase upon burn injury and remain significantly elevated for up to 36 months. D and E, Proinflammatory cytokines are significantly elevated for up to 36 months in response to burn injury. Histograms depict serum concentrations of IL-6 or MCP-1 at steady-state levels. F, REE % predicted increases upon burn injury and decreased over time but remains significantly elevated up to 18 months after injury. Normal range depicted at base of graph (shaded area). Bars represent means; error bars correspond to sem. Asterisks denote statistical difference between burned children vs. nonburned children, P < 0.05.