Table 3.

 Estimates of preventive effect of taking one or more blood pressure lowering drugs on coronary heart disease (CHD) events and stroke according to pretreatment systolic blood pressure, age, number of drugs, and dose (as multiple of standard³³)

Pretreatment systolic blood pressure (mm Hg)	Estimated reduction in systolic blood pressure (mm Hg)*	Relative risk of CHD events by age (years)						Relative risk of stroke by age (years)
		40-49	50-59	60-69	70-79	80-89		40-49	50-59	60-69	70-79	80-89
One drug half standard dose:
180	9.0	0.72	0.73	0.76	0.79	0.83		0.63	0.65	0.68	0.73	0.83
170	8.3	0.74	0.75	0.78	0.81	0.85		0.66	0.67	0.71	0.75	0.85
160	7.5	0.77	0.77	0.79	0.83	0.86		0.68	0.70	0.73	0.77	0.86
150	6.7	0.79	0.79	0.81	0.84	0.87		0.71	0.72	0.75	0.79	0.87
140	5.9	0.81	0.81	0.83	0.86	0.89		0.74	0.75	0.78	0.81	0.89
130	5.1	0.83	0.84	0.85	0.88	0.90		0.77	0.78	0.81	0.84	0.90
120	4.4	0.86	0.86	0.87	0.89	0.92		0.80	0.81	0.83	0.86	0.92
One drug standard dose:
180	11.7	0.66	0.67	0.70	0.74	0.79		0.55	0.57	0.61	0.67	0.79
170	10.7	0.68	0.69	0.72	0.76	0.81		0.58	0.60	0.64	0.69	0.81
160	9.7	0.71	0.71	0.74	0.78	0.82		0.61	0.63	0.66	0.71	0.82
150	8.7	0.73	0.74	0.76	0.80	0.84		0.64	0.66	0.69	0.74	0.84
140	7.7	0.76	0.77	0.79	0.82	0.86		0.67	0.69	0.72	0.77	0.86
130	6.7	0.79	0.79	0.81	0.84	0.87		0.71	0.72	0.75	0.79	0.87
120	5.7	0.82	0.82	0.84	0.86	0.89		0.75	0.76	0.79	0.82	0.89
Two drugs half standard dose:
180	18.0	0.53	0.54	0.57	0.63	0.70		0.40	0.42	0.47	0.54	0.70
170	16.4	0.56	0.57	0.60	0.66	0.72		0.43	0.45	0.50	0.57	0.72
160	14.5	0.59	0.60	0.63	0.68	0.74		0.47	0.49	0.53	0.60	0.74
150	13.3	0.62	0.63	0.66	0.71	0.77		0.51	0.53	0.57	0.63	0.77
140	11.7	0.66	0.67	0.70	0.74	0.79		0.55	0.57	0.61	0.67	0.79
130	10.2	0.70	0.70	0.73	0.77	0.82		0.59	0.61	0.65	0.70	0.82
120	8.6	0.74	0.74	0.77	0.80	0.84		0.64	0.66	0.70	0.74	0.84
Two drugs standard dose:
180	22.2	0.45	0.46	0.50	0.57	0.64		0.32	0.34	0.39	0.46	0.64
170	20.3	0.48	0.49	0.53	0.59	0.67		0.35	0.37	0.42	0.47	0.67
160	18.4	0.52	0.53	0.57	0.62	0.69		0.39	0.41	0.46	0.53	0.69
150	16.5	0.55	0.56	0.60	0.66	0.72		0.43	0.45	0.50	0.56	0.72
140	14.6	0.59	0.60	0.64	0.69	0.75		0.47	0.49	0.54	0.60	0.75
130	12.7	0.64	0.64	0.68	0.72	0.77		0.52	0.54	0.58	0.64	0.77
120	10.8	0.68	0.69	0.72	0.76	0.81		0.58	0.59	0.63	0.69	0.81
Three drugs half standard dose:
180	26.9	0.38	0.39	0.44	0.50	0.58		0.25	0.27	0.32	0.39	0.58
170	24.6	0.42	0.43	0.47	0.53	0.61		0.28	0.30	0.35	0.43	0.61
160	22.2	0.45	0.46	0.50	0.57	0.64		0.32	0.34	0.39	0.46	0.64
150	19.9	0.49	0.50	0.54	0.60	0.67		0.36	0.38	0.43	0.50	0.67
140	17.6	0.50	0.51	0.55	0.61	0.68		0.37	0.39	0.44	0.54	0.68
130	15.2	0.58	0.59	0.63	0.68	0.74		0.46	0.48	0.53	0.59	0.74
120	12.9	0.63	0.64	0.67	0.72	0.77		0.52	0.54	0.58	0.64	0.77
Three drugs standard dose:
180	31.7	0.32	0.33	0.38	0.44	0.53		0.20	0.22	0.26	0.33	0.53
170	29.0	0.36	0.37	0.41	0.48	0.56		0.23	0.25	0.29	0.37	0.56
160	26.3	0.39	0.40	0.44	0.51	0.59		0.26	0.28	0.33	0.40	0.59
150	23.6	0.43	0.44	0.48	0.55	0.62		0.30	0.32	0.37	0.44	0.62
140	20.9	0.48	0.49	0.53	0.59	0.66		0.34	0.36	0.41	0.49	0.66
130	18.2	0.52	0.53	0.57	0.63	0.70		0.40	0.42	0.46	0.53	0.70
120	15.5	0.58	0.59	0.62	0.67	0.73		0.45	0.47	0.52	0.59	0.73

This table is a numerical expansion of figure 7 (systolic blood pressure). Estimates calculated using a two stage procedure in which the effect of drug treatment in reducing systolic blood pressure was first estimated,³² then the effect of this blood pressure reduction on disease risk.²⁵

*See Methods (section headed “Predicting the trial results.”)