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. 1999 May 25;96(11):6125–6130. doi: 10.1073/pnas.96.11.6125

Figure 5.

Figure 5

Model for the role of the SRm160/300 splicing coactivator in ESE function. Interactions involving the binding of hTra2β to a GAA-repeat ESE and U1 snRNP to the 5′ splice site are required to recruit SRm160/300 to the pre-mRNA. Since neither of these interactions alone is sufficient for SRm160/300 recruitment, it is proposed that interactions mediated by one or more SR proteins between SRm160/300 and U1 snRNP, and between SRm160/300 and the ESE, promote spliceosome formation and splicing. These interactions simultaneously promote the binding of U2 snRNP to the pre-mRNA, which also interacts with SRm160/300. It is proposed that these interactions promote the pairing of specific pairs of exons during the regulation of splice site selection.