Table 4. Strain-specific diagnostic features in Tga20 mice.
Scrapie strain | |||
22L | ME7 | RML | |
Plaque-like PrPSc deposits in the granular layer of the cerebellum | + | − | − |
Dense PrPSc plaques in the cortex and hippocampus | − | + | − |
PrPSc staining of cerebellum | + | − | − |
Diffuse PrPSc deposits in cortex and hippocampus | + | − | + |