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. 2009 May 29;4(5):e5735. doi: 10.1371/journal.pone.0005735

Figure 1. MTAP metabolic pathway.

Figure 1

In normal cells, MTAP cleaves MTA, a by-product of polyamine biosynthesis, into adenine and MTR-1-P. Adenine is converted to AMP by the ubiquitous enzyme APRT, with PRPP serving as donor of the phosphoribosyl group. MTR-1-P is converted by a series of steps to methionine. AMP is also produced in cells by de novo purine biosynthesis. In addition to APRT, other cellular phosphoribosyltransferases (PRTs), such as hypoxanthine-guanine phsophoribosyl transferase and orotate phosphoribosyltranferase, covert purines and pyrimidines to nucleotides.