Table 4.
Classification of proteins with statistically significant changes based on Gene Ontology
| Protein | Log2 ratio year one relative to baseline | P-value |
|---|---|---|
| Blood coagulation and inflammation | ||
| Vitronectin (VTN) | 0.374 | 9.27E-08 |
| Ceruloplasmin (CP) [59] | 0.789 | 1.51E-06 |
| Plasminogen (PLG) [51] | 0.307 | 1.50E-06 |
| Kininogen (KNG1) [52] | 0.265 | 2.89E-05 |
| Coagulation factor XII (F12) [52] | 0.364 | 4.64E-05 |
| Coagulation factor IX (F9) | 0.558 | 8.34E-05 |
| Coagulation factor X (F10) | 0.332 | 0.00029 |
| Carboxypeptidase N, polypeptide 1 (CPN1) | 0.288 | 0.0002 |
| Platelet basic protein (PPBP) | 0.273 | 0.00363 |
| Tissue factor pathway inhibitor (TFPI) [51] | -0.267 | 0.01152 |
| Fibrinogen gamma chain (FGG) | 0.273 | 0.01848 |
| Matrix metalloproteinase 2 (MMP2) | -0.681 | 0.03019 |
| Protein Z, vitamin K-dependent plasma glycoprotein (PROZ) | 0.676 | 0.03401 |
| Hyaluronan-binding protein 2 (HABP2) | 0.324 | 0.00029 |
| Metabolism | ||
| Sex hormone binding globulin (SHBG) [68] | 1.381 | 2.30E-07 |
| Insulin-like growth factor binding protein 1 (IGFBP1) [18] | 1.318 | 3.82E-05 |
| Insulin-like growth factor binding protein 4 (IGFBP4) [18] | 0.773 | 8.61E-06 |
| Apolipoprotein A-II (APOA2) [57] | 0.379 | 4.06E-06 |
| Vitamin D binding protein (GC) [59] | 0.298 | 5.82E-06 |
| Apolipoprotein D (APOD) [57] | -0.396 | 0.00133 |
| Insulin-like growth factor binding protein 6 (IGFBP6) | 0.303 | 0.00225 |
| Insulin-like growth factor (IGF1) [18] | -0.410 | 0.00366 |
| Proprotein convertase subtilisin kexin 9 (PCSK9) | 0.385 | 0.02486 |
| Serpin peptidase inhibitor, clade A, member 6 (SERPINA6) | 0.377 | 0.02446 |
| Osteogenesis | ||
| Fetuin B (FETUB) | 0.748 | 2.81E-07 |
| Macrophage stimulating protein 1 (MST1) | 0.546 | 0.00154 |
| Collagen type 1, alpha 1 (COL1A1) | -0.494 | 0.00023 |
| Tolloid-like protein 1, bone morphogenetic protein 1 (TLL1) | -1.150 | 0.0467 |
| Neurogenic locus notch homolog protein 2 (NOTCH2) | -0.289 | 0.01946 |
| Neurogenic locus notch homolog protein 3 (NOTCH3) | -0.622 | 0.02133 |
| Fetuin A (AHSG) [59] | 0.281 | 1.16E-06 |
| Cell growth | ||
| Inhibin, beta E (INHBE) | 0.472 | 0.01866 |
| Follistatin-like 3 (FSTL3) | -0.353 | 0.02042 |
| Transforming growth factor-beta-induced protein ig-h3 (TGFBI) | 0.322 | 0.0036 |
| Complement and immune response | ||
| Serpin peptidase inhibitor, clade G, member 1 (SERPING1) | 0.551 | 0.01216 |
| Complement C2 (C2) | 0.333 | 0.00215 |
| Complement factor H-related protein 5 (CFHL5) | 0.294 | 6.72E-05 |
| Complement factor B (BF) | 0.271 | 1.06E-06 |
| Pantetheinase (VNN1) | 0.564 | 0.00079 |
| Leucine-rich alpha-2-glycoprotein (LRG1) | 0.539 | 0.00031 |
| Neutrophil defensin 1 (DEFA1) | 0.303 | 0.00683 |
| Mannose-binding protein C (MBL2) | -0.300 | 0.00094 |
| TRAF-type zinc finger domain-containing protein 1 (TRAFD1) | -3.863 | 0.00762 |
| Lactotransferrin (LTF) [69] | 0.285 | 0.04264 |
| Trefoil factor 3 (TFF3) | 1.936 | 0.00019 |
| Vessel morphogenesis | ||
| Autotaxin (ENPP2) | 0.581 | 0.00395 |
| Vasorin (SLITL2) | -0.383 | 0.01997 |
| Transgelin 2 (TAGLN2) | -0.542 | 0.01725 |
| Endothelial differentiation G-protein coupled receptor 3 (EDG3) | -2.998 | 0.00033 |
| Cardiomyopathy associated protein 5 (CMYA5) | -4.1374 | 0.01562 |
| Other | ||
| Angiotensinogen (AGT) [15,16] | 1.148 | 7.16E-10 |
| Cathepsin S (CTSS) | 0.588 | 0.04665 |
| Galectin-3-binding protein (LGALS3BP) | 0.416 | 0.00214 |
| Galectin 1 (LGALS1) | 0.305 | 0.02924 |
| E3 ubiquitin-protein ligase UBR1 (UBR1) | -0.422 | 0.00511 |
| Tropomyosin alpha-4 chain (TPM4) | -1.258 | 0.0269 |
| DNA helicase B (HELB) | -1.862 | 0.02157 |
| Putative Polycomb group protein ASXL1 (ASXL1) | -2.658 | 0.02290 |
| Protein CREG2 (CREG2) | ||
| Protein RIC1 homolog (KIAA1432) | -4.153 | 0.00155 |
| Protein FAM59B (FAM59B) | -2.755 | 0.00119 |
| KH homology domain-containing protein 1 (C6orf148) | -3.060 | 0.00116 |
| Alpha-1B-glycoprotein (A1BG) | 0.331 | 1.82E-06 |
| Disks large homolog 2 (DLG2) | 1.749 | 0.04913 |
Proteins with prior associations with ET are indicated with numbered references.