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. Author manuscript; available in PMC: 2009 May 20.
Published in final edited form as: Free Radic Biol Med. 2008 Nov 21;46(4):492–501. doi: 10.1016/j.freeradbiomed.2008.11.003

Fig. 6.

Fig. 6

Reduced p62 expression and increased damage to the p62promoter. (A) Equal amounts of tissue homogenate protein (50 μg) from WT and transgenic AD mice were western blotted with anti-p62 and anti-actin antibodies. p62 expression levels in normal and AD brains were expressed as the ratio of the relative intensity of the p62 blot to actin blot (Mean +/− S.D., *p < 0.05). (B) Oxidative damage in the amplicon within the mouse p62 promoter region of NonTg and 3xTg-AD mouse brains. NonTg and 3xTg-AD mice brain tissues were used to prepare genomic DNA. Real- time PCR was performed with specific primers for the amplicon designed within the mouse p62 gene 5′-flanking region. *p < 0.05, significant difference.