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Schematic representation of Nef gene sequence present in infectious molecular clone of SIVmac239. Nef reading frame begins at nucleotide 9348 and ends at 10139 (numbering of Regier and Desrosiers, 1990) (Regier and Desrosiers, 1990). A T to C point mutation was introduced at position 9841 in the downstream 3′ region (9840-9866) encoding the Mamu B*17-restricted SIV Nef IW9 epitope leading to an isoleucine to threonine switch at position 1 of the 9-mer Nef CTL epitope.
