Table 1.

Phase-III trials comparing chemoradiotherapy to radiotherapy alone

Trial	No. patients	Chemotherapy	Radiation dose	5-Year survival (%)
Araujo et al.85
RT	28	5-FU, MMC, Bleomycin	50	6
chemoradiotherapy	31		50	16
Slabber et al.86
RT	34		40 SC	6 months†
chemoradiotherapy	36	5-FU	40 SC	5 months
*Smith et al.87
RT	62		40–60	7
chemoradiotherapy	65	5-FU, MMC	40–60	9
Wobbes, et al.88
RT	111		40 SC	7.9 months†
chemoradiotherapy	110	Cisplatin	40 SC	9.6 months
Herskovic et al.3
RT	62		64	0
chemoradiotherapy	61	Cisplatin, 5-FU	50	26
Zupanc. et al.89
RT	52		60 non-SC	14.5
chemoradiotherapy	55	Cisplatin, 5-FU	40 SC	24.5

^*Surgery allowed after 40 Gy

^†Median Survival

Abbreviations: RT = radiotherapy; 5-FU = 5-fluorouracil; MMC = mitomycin C; SC = split course